Test Name: ALPHA 1 ANTITRYPSIN
EPIC Search Term: LABAAT
Synonyms: ALPHA AAT ALPHA1
ALPHA-1 ANTITRYPSIN QUANTITATION
Preferred Container: 1 x 1 mL Red With Clot Activator
Sample Type: Blood
Minimum Volume: 1.0 mL
Testing Frequency: Mon - Fri with 12 noon cut off
Expected Turn Around Time: 72 hours
Clinical Application: Alpha-1-antitrypsin (A1A) is the most abundant serum protease inhibitor and inhibits trypsin and elastin, as well as several other proteases. The release of proteolytic enzymes from plasma onto organ surfaces and into tissue spaces results in tissue damage unless inhibitors are present. Congenital deficiency of A1A is associated with the development of emphysema at an unusually early age and with an increased incidence of neonatal hepatitis, usually progressing to cirrhosis.

This test is useful in:
Work-up of individuals with suspected disorders such as familial chronic obstructive lung disease
Diagnosis of alpha-1-antitrypsin deficiency but should be used in conjuction with phenotyping and/or genotyping since alpha 1 antitrypsin is an acute phase protein

Methodology: Nephelometry
Reference Ranges: Age mg/dL
0 1 yr 92 282
1 4 yrs 94 156
4 13 yrs 102 159
> 14 yrs 97 203
Unit of Measure: mG/dL
Test Performed By: Texas Children's Hospital Pathology Services

Available at TCH Main Campus: 832-824-5152
6621 Fannin, MC 1-2261
Houston, TX 77030-2399
Lab Section: Chemistry