Test Name: SIROLIMUS
EPIC Search Term: LABSIRO
Synonyms: This test requires its own tube. SIRO RAPAMYCIN
Preferred Container: 1 x 1 mL Purple EDTA Tube
Sample Type: Blood
Special Collection Instructions: Consult 'TCH Drug Information and
Formulary' site provided by TCH Pharmacy Department, for
therapeutic drug administration and collection instructions. Drug Information and Formulary
Causes for Rejection: Clotted sample
Testing Frequency: Specimen ordered in LIS and received in Main Lab by 18:30 will be done on the same day.
Batch schedule: 11:00am, 18:30pm

West Campus
Specimens in the laboratory by 9:30am M-F will be tested on the same day. Call the lab for STAT requests.
Expected Turn Around Time: 24 hrs

West Campus
4 hours if received by 9:30 am M-F
Clinical Application: This test can be used for:
Monitoring whole blood sirolimus concentration during therapy, particularly in individuals coadministered CYP3A4 substrates, inhibitors, or inducers


Adjusting dose to optimize immunosuppression while minimizing toxicity (The pharmacokinetic interaction between sirolimus and cyclosporine or tacrolimus increases both therapeutic immunosuppression and the toxicity of these agents; lower doses are required with combined use.)

Evaluating patient compliance

Methodology: Chemiliminescent Microparticle Immunoassay (CMIA)
Reference Ranges: 3-12 NG/ML
Unit of Measure: NG/ML
Test Performed By: Texas Children's Hospital Pathology Services

Available at TCH Main Campus: 832-824-5152
6621 Fannin, MC 1-2261
Houston, TX 77030-2399

Available at TCH West Campus: 832-227-1700
18200 Katy Freeway
Houston, TX 77094

Available at TCH Woodlands Campus: 936-267-5200
17600 Interstate 45 South
The Woodlands, TX 77384
Lab Section: Chemistry